2-Acetamido-5-fluoropyridine

Base Information

• Chemical Name: 2-Acetamido-5-fluoropyridine
• CAS No.: 100304-88-9
• Molecular Formula: C7H7FN2O
• Molecular Weight: 154.144
• Hs Code.: 29333990
• Mol file: 100304-88-9.mol

Synonyms:N-(5-fluoropyridin-2-yl)acetamide;

Chemical Property of 2-Acetamido-5-fluoropyridine

Chemical Property:

• Appearance/Colour: Colorless transparent liquid
• Refractive Index: 1.556
• Boiling Point: 319.9 °C at 760 mmHg
• Flash Point: 147.3 °C
• PSA: 41.99000
• Density: 1.285 g/cm³
• LogP: 1.25210
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Acetamido-5-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 3/7/9-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Acetamido-5-fluoropyridine

There total 4 articles about 2-Acetamido-5-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

Difluoroboryl N-(5-fluoro-2-pyridyl)acetamidate (127773-43-7) → 2-amino-5-fluoropyridine (21717-96-4) + 2-Acetamido-5-fluoropyridine (100304-88-9)

Guidance literature:

With water; for 0.166667h; Heating;

DOI:10.1055/s-1989-27427

Reference yield: 38.0%

2-amino-5-fluoropyridine (21717-96-4) + acetyl chloride (75-36-5) → 2-Acetamido-5-fluoropyridine (100304-88-9)

Guidance literature:

With sodium acetate; In acetone; at 20 ℃; for 0.5h;

DOI:10.1016/j.bioorg.2020.104130

Reference yield: 37.0%

2-Acetamido-5-pyridinediazonium tetrafluoroborate → 2-Acetamido-5-fluoropyridine (100304-88-9) + Difluoroboryl N-(5-fluoro-2-pyridyl)acetamidate (127773-43-7)

Guidance literature:

In xylene; for 1.75h; Heating;

DOI:10.1055/s-1989-27427

upstream raw materials:

Difluoroboryl N-(5-fluoro-2-pyridyl)acetamidate

2-amino-5-fluoropyridine

acetyl chloride

Downstream raw materials:

2-amino-5-fluoropyridine

Refernces

• 1、 Hand,Baker. "Syntheses of 2-chloro- and 2-amino-5-fluoropyridines and isolation of a novel difluoroboryl imidate". . p. 905 - 908. Retrieved 2007/10/02.