N-(3-(2-((3-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide

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Chemical Name:N-(3-(2-((3-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide
CAS No.:1594133-94-4
Molecular Formula:C₂₅H₂₄N₆O₂
Molecular Weight:440.505
Hs Code.:

Synonyms:N-(3-(2-((3-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide

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Chemical Property of N-(3-(2-((3-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide

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Technology Process of N-(3-(2-((3-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide

There total 4 articles about N-(3-(2-((3-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1594134-02-7
N-(3-(2-((3-morpholinophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide

: 1594133-94-4
N-(3-(2-((3-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide

Guidance literature:: With hydrogenchloride; water; In ethanol; at 2 ℃; Reflux;

Reference yield:

: 442847-52-1
2,4-dichloro-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3 -d]pyrimidine

: 1594133-94-4
N-(3-(2-((3-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; palladium diacetate; triphenylphosphine / tetrahydrofuran; water / 2 h / 150 °C / Microwave irradiation

2: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tert-butyl alcohol / 160 °C / Microwave irradiation

3: hydrogenchloride; water / ethanol / 2 °C / Reflux

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethanol; water; tert-butyl alcohol;

Reference yield:

: 1594134-01-6
N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide

: 1594133-94-4
N-(3-(2-((3-morpholinophenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tert-butyl alcohol / 160 °C / Microwave irradiation

2: hydrogenchloride; water / ethanol / 2 °C / Reflux

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; tert-butyl alcohol;