N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide
CAS No.:1594134-01-6
Molecular Formula:C₂₁H₂₅ClN₄O₂Si
Molecular Weight:428.994
Hs Code.:

Synonyms:N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide

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Chemical Property of N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide

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Technology Process of N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide

There total 4 articles about N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1594134-01-6
N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 442847-52-1
2,4-dichloro-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3 -d]pyrimidine

: 99349-68-5
(3-acrylamidophenyl)boronic acid

: 1594134-01-6
N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; at 150 ℃; for 2h; Microwave irradiation;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1594134-01-6
N-(3-(2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyramidin-4-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 20 °C

2.1: sodium carbonate; palladium diacetate; triphenylphosphine / tetrahydrofuran; water / 2 h / 150 °C / Microwave irradiation

With palladium diacetate; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide;