2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL

Base Information

• Chemical Name: 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL
• CAS No.: 444341-80-4
• Molecular Formula: C8H6ClF3O2
• Molecular Weight: 226.583
• Hs Code.: 2909500000
• Mol file: 444341-80-4.mol

Synonyms:2-Chloro-4-(2,2,2-trifluoroethoxy)phenol;2-Chloro-4-(trifluoroethoxy)-phenol;

Chemical Property of 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL

Chemical Property:

• Vapor Pressure: 0.021mmHg at 25°C
• Refractive Index: 1.484
• Boiling Point: 243.382 °C at 760 mmHg
• Flash Point: 100.994 °C
• PSA: 29.46000
• Density: 1.446 g/cm³
• LogP: 2.98670
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4-(2,2,2-trifluoroethoxy)phenol 95+% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL

There total 4 articles about 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(2,2,2-trifluoroethoxy)phenol (129560-99-2) → 2-chloro-4-(2,2,2-trifluoroethoxy)phenol (444341-80-4)

Guidance literature:

With diisobutylamine; sulfuryl dichloride; In toluene; at 25 ℃; for 2h;

DOI:10.1021/jm050373g

Reference yield:

diisobutylamine (110-96-3) + 4-(2,2,2-trifluoroethoxy)phenol (129560-99-2) → 2-chloro-4-(2,2,2-trifluoroethoxy)phenol (444341-80-4)

Guidance literature:

With sulfuryl dichloride; In toluene;

Reference yield:

1-(benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene (200956-20-3) → 2-chloro-4-(2,2,2-trifluoroethoxy)phenol (444341-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂ / Pd/C

2: SO₂Cl₂; diisobutylamine

With diisobutylamine; sulfuryl dichloride; hydrogen; palladium on activated charcoal;

DOI:10.1016/j.bmcl.2005.05.028

upstream raw materials:

4-(2,2,2-trifluoroethoxy)phenol

1-(benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene

4-Benzyloxyphenol

diisobutylamine

Downstream raw materials:

5-{3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-phenoxy]-propoxy}-2-methyl-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester