1-(BENZYLOXY)-4-(2,2,2-TRIFLUOROETHOXY)BENZENE

Base Information

• Chemical Name: 1-(BENZYLOXY)-4-(2,2,2-TRIFLUOROETHOXY)BENZENE
• CAS No.: 200956-20-3
• Molecular Formula: C15H13 F3 O2
• Molecular Weight: 282.262
• Hs Code.: 2909309090
• Mol file: 200956-20-3.mol

Synonyms:Benzyl4-(2,2,2-trifluoroethoxy)phenyl ether

Chemical Property of 1-(BENZYLOXY)-4-(2,2,2-TRIFLUOROETHOXY)BENZENE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.511
• Boiling Point: 335.6°Cat760mmHg
• Flash Point: 164.8°C
• PSA: 18.46000
• Density: 1.221g/cm³
• LogP: 4.20670

Purity/Quality:

97% ^*data from raw suppliers

1-(BENZYLOXY)-4-(2,2,2-TRIFLUOROETHOXY)BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(BENZYLOXY)-4-(2,2,2-TRIFLUOROETHOXY)BENZENE

There total 4 articles about 1-(BENZYLOXY)-4-(2,2,2-TRIFLUOROETHOXY)BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Benzyloxyphenol (103-16-2) + 2,2,2-trifluoroethyl trifluoromethanesulphonate (6226-25-1) → 1-(benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene (200956-20-3)

Guidance literature:

With caesium carbonate; In acetonitrile; at 85 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.10.097

Reference yield: 73.0%

2,2,2-trifluoroethanol (75-89-8) + [4-(benzyloxy)phenyl]boronic acid (146631-00-7) → 1-(benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene (200956-20-3)

Guidance literature:

With dmap; oxygen; copper(II) acetate monohydrate; at 40 ℃; for 1h;

DOI:10.1016/j.tetlet.2015.06.066

Reference yield:

4-Benzyloxyphenol (103-16-2) + 2,2,2-Trifluoroethyl p-toluenesulfonate (433-06-7) → 1-(benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene (200956-20-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 22h;

upstream raw materials:

4-Benzyloxyphenol

2,2,2-trifluoroethyl trifluoromethanesulphonate

2,2,2-trifluoroethanol

[4-(benzyloxy)phenyl]boronic acid

Downstream raw materials:

4-(2,2,2-trifluoroethoxy)phenol

4-Benzyloxyphenol

3-bromopropyl 2-chloro-4-(2,2,2-trifluoroethoxy)phenyl ether

2-chloro-4-(2,2,2-trifluoroethoxy)phenol