phenylmethyl [(2R,4S)-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate

Base Information

Chemical Name:phenylmethyl [(2R,4S)-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate
CAS No.:1193336-41-2
Molecular Formula:C₂₃H₂₇FN₂O₂
Molecular Weight:382.478
Hs Code.:

Synonyms:phenylmethyl [(2R,4S)-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate

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Chemical Property of phenylmethyl [(2R,4S)-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate

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Technology Process of phenylmethyl [(2R,4S)-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate

There total 3 articles about phenylmethyl [(2R,4S)-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1193336-40-1
1,1-dimethylethyl (2R,4S)-2-(4-fluoro-2-methylphenyl)-4-({[(phenylmethyl)oxy]carbonyl}amino)-4-(2-propen-1-yl)-1-piperidinecarboxylate

: 1193336-41-2
phenylmethyl [(2R,4S)-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate

Guidance literature:: 1,1-dimethylethyl (2R,4S)-2-(4-fluoro-2-methylphenyl)-4-({[(phenylmethyl)oxy]carbonyl}amino)-4-(2-propen-1-yl)-1-piperidinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2.5h;

With sodium hydrogencarbonate; In dichloromethane; water; pH=8;

Reference yield:

: 1193336-39-8
1,1-dimethylethyl (2R,4S)-4-amino-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-1-piperidinecarboxylate

: 1193336-41-2
phenylmethyl [(2R,4S)-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

2.2: pH 8

With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 414910-12-6
(2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone

: 1193336-41-2
phenylmethyl [(2R,4S)-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: (S)-Mandelic acid; triethylamine / dichloromethane / 20 °C

2.1: ammonia / methanol / 0.25 h / 20 °C

2.2: 20 °C

3.1: dichloromethane / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

4.2: pH 8

With (S)-Mandelic acid; ammonia; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;