6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-(p-tolyl)-1,2,4-triazine

Base Information

Chemical Name:6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-(p-tolyl)-1,2,4-triazine
CAS No.:1542256-73-4
Molecular Formula:C₁₈H₁₇N₃O₂S₂
Molecular Weight:371.484
Hs Code.:

Synonyms:6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-(p-tolyl)-1,2,4-triazine

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Chemical Property of 6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-(p-tolyl)-1,2,4-triazine

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Technology Process of 6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-(p-tolyl)-1,2,4-triazine

There total 6 articles about 6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-(p-tolyl)-1,2,4-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1542256-68-7
C₁₇H₁₅N₃O₂S₂

: 74-88-4
methyl iodide

: 1542256-73-4
6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-(p-tolyl)-1,2,4-triazine

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2013.12.002

Reference yield:

: 622-47-9
4-tolylacetic acid

: 1542256-73-4
6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-(p-tolyl)-1,2,4-triazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic anhydride / phosphoric acid / 0.08 h / 20 °C

2.1: Oxone / methanol; tetrahydrofuran / 4 h / 20 °C

3.1: sodium methylate / methanol / 20 °C

3.2: 20 °C

4.1: hydrogenchloride / water / Reflux

5.1: triethylamine / methanol / 0.5 h / 20 °C

With hydrogenchloride; sodium methylate; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; phosphoric acid; water;
DOI:10.1016/j.bmc.2013.12.002

Reference yield:

: 708276-16-8
2-(4-methylphenyl)-1-(4-methylsulfanylphenyl)ethanone

: 1542256-73-4
6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-5-(p-tolyl)-1,2,4-triazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Oxone / methanol; tetrahydrofuran / 4 h / 20 °C

2.1: sodium methylate / methanol / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / water / Reflux

4.1: triethylamine / methanol / 0.5 h / 20 °C

With hydrogenchloride; sodium methylate; triethylamine; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2013.12.002