7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine
CAS No.:1354803-35-2
Molecular Formula:C₁₉H₁₇ClFN₃O
Molecular Weight:357.815
Hs Code.:

Synonyms:7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine

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Chemical Property of 7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine

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Technology Process of 7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine

There total 1 articles about 7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354801-88-9
9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine

: 79-04-9
chloroacetyl chloride

: 1354803-35-2
7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine

Guidance literature:: With triethylamine; In tetrahydrofuran; for 0.5h;

Reference yield:

: 1354803-35-2
7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine

: 3-amino-2,2-dimethyl-propionic acid methyl ester HCl salt

: 1354803-55-6
C₂₅H₂₉FN₄O₃

Guidance literature:: 7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine; 3-amino-2,2-dimethyl-propionic acid methyl ester HCl salt; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With tetrabutylammomium bromide; In tetrahydrofuran; at 60 ℃; for 14h;

Reference yield:

: 1354803-35-2
7-(chloroacetyl)-9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine

: 1354803-37-4
3-{2-[9-(3-fluorobenzyl)-5,6,8,9-tetrahydro-7H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridin-7-yl]-2-oxoethoxy}-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 1 h

2.1: sodium hydroxide / 1,2-dimethoxyethane; methanol; water / 20 °C

With sodium hydride; sodium hydroxide; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;