(R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine

Base Information

Chemical Name:(R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine
CAS No.:177283-81-7
Molecular Formula:C₂₇H₄₀N₂O₂
Molecular Weight:424.627
Hs Code.:

Synonyms:(R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine

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Chemical Property of (R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine

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Technology Process of (R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine

There total 1 articles about (R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1-{(4S,5S)-5-[1-[(E)-Hydroxyimino]-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethanone oxime

: 177283-81-7
(R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine

Guidance literature:: With diisobutylaluminium hydride; In toluene; a) RT, overnight, b) 50 deg C, 2 h;
DOI:10.1021/jm960083n

Reference yield:

: 177283-81-7
(R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine

: 177284-11-6
(3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1,1,2,2-tetrachloroethane, 25 deg C, 10 min, 2.) 1,1,2,2-tetrachloroethane, reflux

2: 92 percent / potassium tert-butoxide / tetrahydrofuran / 0.5 h / Ambient temperature

With potassium tert-butylate; In tetrahydrofuran;
DOI:10.1021/jm960083n

Reference yield:

: 177283-81-7
(R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine

: (4R,5S,6S,7R)-1,3-Dibenzyl-5,6-dihydroxy-4,7-bis-(4-isopropyl-benzyl)-[1,3]diazepan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1,1,2,2-tetrachloroethane, 25 deg C, 10 min, 2.) 1,1,2,2-tetrachloroethane, reflux

2: 92 percent / potassium tert-butoxide / tetrahydrofuran / 0.5 h / Ambient temperature

3: 73 percent / 6.7percent aq. HCl / methanol / 2 h

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; methanol;
DOI:10.1021/jm960083n