(3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Base Information

Chemical Name:(3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one
CAS No.:177284-11-6
Molecular Formula:C₄₂H₅₀N₂O₃
Molecular Weight:630.871
Hs Code.:

Synonyms:(3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

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Chemical Property of (3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

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Technology Process of (3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

There total 3 articles about (3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-39-0
benzyl bromide

: 177283-80-6
(3aS,4R,8R,8aS)-4,8-Bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

: 177284-11-6
(3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1021/jm960083n

Reference yield:

: 177283-81-7
(R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethylamine

: 177284-11-6
(3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1,1,2,2-tetrachloroethane, 25 deg C, 10 min, 2.) 1,1,2,2-tetrachloroethane, reflux

2: 92 percent / potassium tert-butoxide / tetrahydrofuran / 0.5 h / Ambient temperature

With potassium tert-butylate; In tetrahydrofuran;
DOI:10.1021/jm960083n

Reference yield:

: 1-{(4S,5S)-5-[1-[(E)-Hydroxyimino]-2-(4-isopropyl-phenyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(4-isopropyl-phenyl)-ethanone oxime

: 177284-11-6
(3aS,4R,8R,8aS)-5,7-Dibenzyl-4,8-bis-(4-isopropyl-benzyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / diisobutylaluminum hydride / toluene / a) RT, overnight, b) 50 deg C, 2 h

2: 1.) 1,1,2,2-tetrachloroethane, 25 deg C, 10 min, 2.) 1,1,2,2-tetrachloroethane, reflux

3: 92 percent / potassium tert-butoxide / tetrahydrofuran / 0.5 h / Ambient temperature

With potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; toluene;
DOI:10.1021/jm960083n