7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one

Base Information

Chemical Name:7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one
CAS No.:1147529-48-3
Molecular Formula:C₃₄H₃₇N₇O₄
Molecular Weight:607.712
Hs Code.:

7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one

Synonyms:7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one

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Chemical Property of 7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one

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Technology Process of 7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one

There total 8 articles about 7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-tert-butyl-3-{2-methyl-3-[1-methyl-5-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-3H-quinazolin-4-one

: 1147529-48-3
7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; pH=~ 3;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 1147529-48-3
7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

2.1: hydrogen; palladium on activated charcoal / ethanol / 6 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 40 h / 20 °C / Inert atmosphere

4.1: 0.5 h / 105 °C / Inert atmosphere

4.2: 1 h / Inert atmosphere; Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.21 h / 170 °C / Inert atmosphere; Microwave irradiation

6.1: hydrogenchloride; sodium cyanoborohydride / methanol / 0.75 h / pH 3 / Inert atmosphere

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; potassium acetate; sodium cyanoborohydride; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 5.1: |Suzuki Coupling;
DOI:10.1021/jm500305p

Reference yield:

: 910235-64-2
2-(2-methyl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1147529-48-3
7-tert-butyl-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-2,3-dihydro-1H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; palladium on activated charcoal / ethanol / 6 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 40 h / 20 °C / Inert atmosphere

3.1: 0.5 h / 105 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere; Reflux

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.21 h / 170 °C / Inert atmosphere; Microwave irradiation

5.1: hydrogenchloride; sodium cyanoborohydride / methanol / 0.75 h / pH 3 / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; sodium cyanoborohydride; sodium carbonate; triethylamine; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 4.1: |Suzuki Coupling;
DOI:10.1021/jm500305p