N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester

Base Information

• Chemical Name: N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester
• CAS No.: 628280-42-2
• Molecular Formula: C₃₀H₃₀N₂O₉
• Molecular Weight: 562.576
• Mol file: 628280-42-2.mol

Synonyms:N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester

Chemical Property of N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester

There total 5 articles about N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

→ N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester (628280-42-2)

Guidance literature:

Reference yield:

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine (73724-45-5) → N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester (628280-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tricaprylmethylammonium chloride; aq. NaHCO₃ / CH₂Cl₂ / 24 h / 20 °C

2: CF₃SO₃H / CH₂Cl₂ / 20 °C

With trifluorormethanesulfonic acid; Aliquat 336; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1021/ja037801x

Reference yield:

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine (73724-45-5) → N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester (628280-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; Aliquat 336 / water; dichloromethane / 24 h / 20 °C

2: trifluorormethanesulfonic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With trifluorormethanesulfonic acid; Aliquat 336; sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1002/anie.201309691

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-L-serine allyl ester

4,5-dimethoxy-2-nitrobenzyl trichloroacetimidate

6-nitroveratryl alcohol

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

Downstream raw materials:

(S)-2-Amino-3-(4,5-dimethoxy-2-nitro-benzyloxy)-propionic acid

N-(9-Fluorenylmethyloxycarbonyl)-O-(4,5-dimethoxy-2-nitrobenzyl)-L-serine