N-Fmoc DMNB-L-serine

Base Information

Chemical Name:N-Fmoc DMNB-L-serine
CAS No.:628280-43-3
Molecular Formula:C27H26N2O9
Molecular Weight:522.511
Hs Code.:
DSSTox Substance ID:DTXSID50514485
Nikkaji Number:J1.969.399F
Wikidata:Q82374843
Mol file:628280-43-3.mol

Synonyms:N-Fmoc DMNB-L-serine;628280-43-3;(2S)-3-[(4,5-dimethoxy-2-nitrophenyl)methoxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid;SCHEMBL3426426;DTXSID50514485;O-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-serine

Suppliers and Price of N-Fmoc DMNB-L-serine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-FmocDMNB-L-serine
50mg
$ 1760.00

Total 2 raw suppliers

Chemical Property of N-Fmoc DMNB-L-serine

Chemical Property:

PSA：152.63000
LogP:4.84810
XLogP3:3.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:11
Exact Mass:522.16383041
Heavy Atom Count:38
Complexity:799

Purity/Quality:

97% ^*data from raw suppliers

N-FmocDMNB-L-serine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C(=C1)COCC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)[N+](=O)[O-])OC
Isomeric SMILES:COC1=C(C=C(C(=C1)COC[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)[N+](=O)[O-])OC
Uses A photolytically labile serine molecule, able to be incorporated into short peptides to create caged protein kinase sensors, allowing measurement of intracellular enzymatic activity.

Technology Process of N-Fmoc DMNB-L-serine

There total 7 articles about N-Fmoc DMNB-L-serine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

: 628280-43-3
N-(9-Fluorenylmethyloxycarbonyl)-O-(4,5-dimethoxy-2-nitrobenzyl)-L-serine

Guidance literature:: Multi-step reaction with 3 steps

1: tricaprylmethylammonium chloride; aq. NaHCO₃ / CH₂Cl₂ / 24 h / 20 °C

2: CF₃SO₃H / CH₂Cl₂ / 20 °C

3: Pd(Ph₃P)4; N-methylmorpholine; acetic acid / CHCl₃ / 4 h / 20 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluorormethanesulfonic acid; Aliquat 336; sodium hydrogencarbonate; acetic acid; In dichloromethane; chloroform;
DOI:10.1021/ja037801x

Reference yield:

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

: 628280-43-3
N-(9-Fluorenylmethyloxycarbonyl)-O-(4,5-dimethoxy-2-nitrobenzyl)-L-serine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; Aliquat 336 / water; dichloromethane / 24 h / 20 °C

2: trifluorormethanesulfonic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: acetic acid; 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / chloroform / 4 h / 20 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluorormethanesulfonic acid; Aliquat 336; sodium hydrogencarbonate; acetic acid; In dichloromethane; chloroform; water;
DOI:10.1002/anie.201309691

Reference yield:

: 628280-42-2
N-(9-fluorenylmethyloxycarbonyl)-o-(4,5-dimethoxy-2-nitrobenzyl)-L-serine allyl ester

: 628280-43-3
N-(9-Fluorenylmethyloxycarbonyl)-O-(4,5-dimethoxy-2-nitrobenzyl)-L-serine

Guidance literature:: With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In chloroform; at 20 ℃; for 4h;
DOI:10.1021/ja037801x