benzyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-{(methylsulfonyl)[4-(propan-2-yl)phenyl]amino}butanoate

Base Information

Chemical Name:benzyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-{(methylsulfonyl)[4-(propan-2-yl)phenyl]amino}butanoate
CAS No.:1369963-20-1
Molecular Formula:C₂₉H₃₀N₂O₆S
Molecular Weight:534.633
Hs Code.:

Synonyms:benzyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-{(methylsulfonyl)[4-(propan-2-yl)phenyl]amino}butanoate

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Chemical Property of benzyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-{(methylsulfonyl)[4-(propan-2-yl)phenyl]amino}butanoate

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Technology Process of benzyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-{(methylsulfonyl)[4-(propan-2-yl)phenyl]amino}butanoate

There total 5 articles about benzyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-{(methylsulfonyl)[4-(propan-2-yl)phenyl]amino}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 1369963-19-8
benzyl N-(methylsulfonyl)-N-[4-(propan-2-yl)phenyl]homoserinate

: 1369963-20-1
benzyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-{(methylsulfonyl)[4-(propan-2-yl)phenyl]amino}butanoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 0.5h; Cooling with ice;

Reference yield:

: 100-39-0
benzyl bromide

: 1369963-20-1
benzyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-{(methylsulfonyl)[4-(propan-2-yl)phenyl]amino}butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / methanol / 1 h / 20 °C

1.2: 20 °C

2.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Cooling with ice; Inert atmosphere

4.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Cooling with ice

With dmap; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; water; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1208982-25-5
benzyl 4-(tert-butyldimethylsiloxy)-2-hydroxybutanoate

: 1369963-20-1
benzyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-{(methylsulfonyl)[4-(propan-2-yl)phenyl]amino}butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Cooling with ice; Inert atmosphere

2: boron trifluoride diethyl etherate / dichloromethane / 1 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Cooling with ice

With di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; triphenylphosphine; In tetrahydrofuran; dichloromethane;