8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:116234-45-8
Molecular Formula:C₁₇H₁₈N₄O
Molecular Weight:294.356
Hs Code.:

Synonyms:8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of 8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 6 articles about 8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 116234-48-1
8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 116234-45-8
8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With sodium azide; sodium nitrite; at 0 ℃;
DOI:10.1021/jm00119a003

Reference yield:

: 116234-47-0
8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 116234-45-8
8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / hydrazine hydrate, Raney nickel / ethanol

2: 55 percent / boron tribromide

3: 64 percent / 1.) sodium nitrite, 2.) sodium azide / 0 °C

With sodium azide; boron tribromide; nickel; hydrazine hydrate; sodium nitrite; In ethanol;
DOI:10.1021/jm00119a003

Reference yield:

: 6388-74-5,38201-14-8,71884-55-4
p-Nitrophenyloxirane

: 116234-45-8
8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / tetrahydrofuran / 24 h / Heating

2: 91 percent / PPA / 2 h / 100 °C

3: 92 percent / 88percent formic acid / H₂O / 24 h / Heating

4: 92 percent / hydrazine hydrate, Raney nickel / ethanol / 50 - 55 °C

5: 80 percent / BBr₃ / CH₂Cl₂; hexane / 1.) -70 deg C, 1 h, 2.) room temp., 3 h

6: 1.) conc. H₂SO₄, sodium nitrite, 2.) sodium azide / 1.) water, 0 deg C, 15 min, 2.) 0 deg C, 2 h

With formic acid; sodium azide; sulfuric acid; boron tribromide; nickel; hydrazine hydrate; sodium nitrite; In tetrahydrofuran; ethanol; hexane; dichloromethane; water;
DOI:10.1021/jm00164a009