Technology Process of 8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
There total 6 articles about 8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / hydrazine hydrate, Raney nickel / ethanol
2: 55 percent / boron tribromide
3: 64 percent / 1.) sodium nitrite, 2.) sodium azide / 0 °C
With
sodium azide; boron tribromide; nickel; hydrazine hydrate; sodium nitrite;
In
ethanol;
DOI:10.1021/jm00119a003
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 65 percent / tetrahydrofuran / 24 h / Heating
2: 91 percent / PPA / 2 h / 100 °C
3: 92 percent / 88percent formic acid / H2O / 24 h / Heating
4: 92 percent / hydrazine hydrate, Raney nickel / ethanol / 50 - 55 °C
5: 80 percent / BBr3 / CH2Cl2; hexane / 1.) -70 deg C, 1 h, 2.) room temp., 3 h
6: 1.) conc. H2SO4, sodium nitrite, 2.) sodium azide / 1.) water, 0 deg C, 15 min, 2.) 0 deg C, 2 h
With
formic acid; sodium azide; sulfuric acid; boron tribromide; nickel; hydrazine hydrate; sodium nitrite;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water;
DOI:10.1021/jm00164a009
