8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:116234-48-1
Molecular Formula:C₁₇H₂₀N₂O
Molecular Weight:268.359
Hs Code.:

Synonyms:8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property:

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Technology Process of 8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 5 articles about 8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 116263-67-3
8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 116234-48-1
8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With boron tribromide; In hexane; dichloromethane; 1.) -70 deg C, 1 h, 2.) room temp., 3 h;
DOI:10.1021/jm00164a009

Reference yield:

: 6388-74-5,38201-14-8,71884-55-4
p-Nitrophenyloxirane

: 116234-48-1
8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / tetrahydrofuran / 24 h / Heating

2: 91 percent / PPA / 2 h / 100 °C

3: 92 percent / 88percent formic acid / H₂O / 24 h / Heating

4: 92 percent / hydrazine hydrate, Raney nickel / ethanol / 50 - 55 °C

5: 80 percent / BBr₃ / CH₂Cl₂; hexane / 1.) -70 deg C, 1 h, 2.) room temp., 3 h

With formic acid; boron tribromide; nickel; hydrazine hydrate; In tetrahydrofuran; ethanol; hexane; dichloromethane; water;
DOI:10.1021/jm00164a009

Reference yield:

: 116351-49-6
α-<methyl>-4-nitrobenzyl alcohol

: 116234-48-1
8-hydroxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / PPA / 2 h / 100 °C

2: 92 percent / 88percent formic acid / H₂O / 24 h / Heating

3: 92 percent / hydrazine hydrate, Raney nickel / ethanol / 50 - 55 °C

4: 80 percent / BBr₃ / CH₂Cl₂; hexane / 1.) -70 deg C, 1 h, 2.) room temp., 3 h

With formic acid; boron tribromide; nickel; hydrazine hydrate; In ethanol; hexane; dichloromethane; water;
DOI:10.1021/jm00164a009