8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Base Information

Chemical Name:8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
CAS No.:109164-79-6
Molecular Formula:C₂₃H₃₆N₂O₄Si
Molecular Weight:432.635
Hs Code.:

Synonyms:8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Suppliers and Price of 8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

There total 7 articles about 8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109164-78-5
4-(3-Bromo-propyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-benzyl)-piperazine-2,5-dione

: 109164-79-6
8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; Yield given;
DOI:10.1016/S0040-4039(00)84854-6

Reference yield:

: 79074-03-6
2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid

: 109164-79-6
8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / dimethylformamide / 0 °C

2: DCC / tetrahydrofuran / 25 °C

3: H₂ / 10percent Pd-C / ethanol / 760 Torr

4: KOtBu / dimethylformamide / 0 °C

5: NaH / dimethylformamide / 25 °C

With potassium tert-butylate; hydrogen; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)84854-6

Reference yield:

: 60857-16-1
N-(4-methoxybenzyl)glycine ethyl ester

: 109164-79-6
8a-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: DCC / tetrahydrofuran / 25 °C

2: H₂ / 10percent Pd-C / ethanol / 760 Torr

3: KOtBu / dimethylformamide / 0 °C

4: NaH / dimethylformamide / 25 °C

With potassium tert-butylate; hydrogen; sodium hydride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)84854-6