2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid

Base Information

• Chemical Name: 2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid
• CAS No.: 109392-77-0
• Molecular Formula: C₁₈H₂₉NO₅Si
• Molecular Weight: 367.517
• Mol file: 109392-77-0.mol

Synonyms:2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid

Chemical Property of 2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid

There total 1 articles about 2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid (79074-03-6) + tert-butyldimethylsilyl chloride (18162-48-6) → 2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid (109392-77-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/S0040-4039(00)84854-6 DOI:10.1021/jo00227a019

Reference yield:

2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid (109392-77-0) → 3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-benzyl)-piperazine-2,5-dione (109164-77-4)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / tetrahydrofuran / 25 °C

2: H₂ / 10percentPd/C / aq. ethanol / 760 Torr

With hydrogen; dicyclohexyl-carbodiimide; 10% palladium on active carbon; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00227a019

Reference yield:

N-(4-methoxybenzyl)glycine ethyl ester (60857-16-1) + 2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid (109392-77-0) → [[2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyryl]-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester (109164-76-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 25 ℃;

DOI:10.1016/S0040-4039(00)84854-6 DOI:10.1021/jo00227a019

upstream raw materials:

2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid

tert-butyldimethylsilyl chloride

Downstream raw materials:

[[2-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyryl]-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-benzyl)-piperazine-2,5-dione

6,8-bis(p-methoxybenzyl)-2-methylene-6,8-diazabicyclo-<2.2.2>octane-5,7-dione

1,4-bis-(p-methoxybenzyl)-3-(formylmethyl)2,5-piperazinedione