2-(4-benzyloxy-3-cyanophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

Base Information

Chemical Name:2-(4-benzyloxy-3-cyanophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate
CAS No.:1292298-95-3
Molecular Formula:C₂₅H₂₈N₂O₆
Molecular Weight:452.507
Hs Code.:

Synonyms:2-(4-benzyloxy-3-cyanophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

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Chemical Property of 2-(4-benzyloxy-3-cyanophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

Chemical Property:

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Technology Process of 2-(4-benzyloxy-3-cyanophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

There total 4 articles about 2-(4-benzyloxy-3-cyanophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 57294-38-9
N-(tert-butoxycarbonyl)-4-aminobutanoic acid

: 50916-47-7
1-(4-benzyloxy-3-cyanophenyl)-2-bromoethanone

: 1292298-95-3
2-(4-benzyloxy-3-cyanophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1139/V10-143

Reference yield:

: 611-20-1
salicylonitrile

: 1292298-95-3
2-(4-benzyloxy-3-cyanophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; trifluoroacetic acid / 20 °C

2: potassium carbonate / acetonitrile / 15 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C

4: phenyltrimethylammonium tribromide / methanol; dichloromethane / 6 h / 20 °C

5: potassium carbonate / acetonitrile / 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; phenyltrimethylammonium tribromide; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; toluene; acetonitrile; 3: Stille coupling;
DOI:10.1139/V10-143

Reference yield:

: 40530-18-5
5-bromo-2-hydroxybenzonitrile

: 1292298-95-3
2-(4-benzyloxy-3-cyanophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 15 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C

3: phenyltrimethylammonium tribromide / methanol; dichloromethane / 6 h / 20 °C

4: potassium carbonate / acetonitrile / 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenyltrimethylammonium tribromide; potassium carbonate; In methanol; dichloromethane; toluene; acetonitrile; 2: Stille coupling;
DOI:10.1139/V10-143