1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]propane-1,3-dione

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]propane-1,3-dione
• CAS No.: 1062682-26-1
• Molecular Formula: C₁₇H₁₃F₃O₃
• Molecular Weight: 322.284
• Mol file: 1062682-26-1.mol

Synonyms:1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]propane-1,3-dione

Chemical Property of 1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]propane-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]propane-1,3-dione

There total 2 articles about 1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl 4-(trifluoromethyl)benzoate (2967-66-0) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]propane-1,3-dione (1062682-26-1)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 - 30 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201300566

Reference yield: 80.0%

4-CF3C6H4CN (455-18-5) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]propane-1,3-dione (1062682-26-1)

Guidance literature:

4-CF₃C₆H₄CN; 2-Bromo-4'-methoxyacetophenone; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; for 6h; Reflux; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 100 ℃; for 0.5h; pH=2; Inert atmosphere;

DOI:10.1002/ejoc.201403402

Reference yield: 89.0%

1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]propane-1,3-dione (1062682-26-1) + 2,6-dichlorophenyl 2-diazo-2-phenylacetate → 2,6-dichlorophenyl 4-(4-methoxyphenyl)-4-oxo-2-phenyl-2-(4-(trifluoromethyl)benzoyl)butanoate

Guidance literature:

With [bis(trifluoromethanesulfonyl)imidate](tris(2,4-di-tert-butylphenyl)phosphite)gold(I); phosphoric acid; In dichloromethane; at 25 ℃; for 3h; chemoselective reaction; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1002/asia.201800934

upstream raw materials:

methyl 4-(trifluoromethyl)benzoate

1-(4-methoxyphenyl)ethanone

4-CF₃C₆H₄CN

2-Bromo-4'-methoxyacetophenone

Downstream raw materials:

C₃₉H₂₇F₆N₅O₂

C₃₉H₂₇F₆N₅O₂

C₃₉H₂₇F₆N₅O₂

C₂₂H₁₆F₃N₃O