2-(2,5-dimethyl-pyrrol-1-yl)-6-(4-[1,3]dioxolan-2-yl-2,5-dimethoxy-phenyl)-pyridine

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Chemical Name:2-(2,5-dimethyl-pyrrol-1-yl)-6-(4-[1,3]dioxolan-2-yl-2,5-dimethoxy-phenyl)-pyridine
CAS No.:762275-75-2
Molecular Formula:C₂₂H₂₄N₂O₄
Molecular Weight:380.444
Hs Code.:

Synonyms:2-(2,5-dimethyl-pyrrol-1-yl)-6-(4-[1,3]dioxolan-2-yl-2,5-dimethoxy-phenyl)-pyridine

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Chemical Property of 2-(2,5-dimethyl-pyrrol-1-yl)-6-(4-[1,3]dioxolan-2-yl-2,5-dimethoxy-phenyl)-pyridine

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Technology Process of 2-(2,5-dimethyl-pyrrol-1-yl)-6-(4-[1,3]dioxolan-2-yl-2,5-dimethoxy-phenyl)-pyridine

There total 3 articles about 2-(2,5-dimethyl-pyrrol-1-yl)-6-(4-[1,3]dioxolan-2-yl-2,5-dimethoxy-phenyl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31558-41-5
4-bromo-2,5-dimethoxybenzaldehyde

: 762275-75-2
2-(2,5-dimethyl-pyrrol-1-yl)-6-(4-[1,3]dioxolan-2-yl-2,5-dimethoxy-phenyl)-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / TsOH / benzene

2.1: BuLi / tetrahydrofuran / -78 °C

2.2: 85 percent / B(OEt)3 / tetrahydrofuran

3.1: Pd(PPh₃)4; aq. Na₂CO₃ / ethanol / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; benzene; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.06.043

Reference yield:

: 198209-31-3
2-bromo6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

: 681171-33-5
2-(4-boronic acid-2,5-dimethoxy-phenyl)-[1,3]dioxolane

: 762275-75-2
2-(2,5-dimethyl-pyrrol-1-yl)-6-(4-[1,3]dioxolan-2-yl-2,5-dimethoxy-phenyl)-pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; at 90 ℃;
DOI:10.1016/j.bmcl.2004.06.043

Reference yield:

: 681171-32-4
2-(4-bromo-2,5-dimethoxy-phenyl)-[1,3]dioxolane

: 762275-75-2
2-(2,5-dimethyl-pyrrol-1-yl)-6-(4-[1,3]dioxolan-2-yl-2,5-dimethoxy-phenyl)-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran / -78 °C

1.2: 85 percent / B(OEt)3 / tetrahydrofuran

2.1: Pd(PPh₃)4; aq. Na₂CO₃ / ethanol / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; In tetrahydrofuran; ethanol; 2.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.06.043