4-(5-(4-Fluorophenyl)-4-(4-methoxyphenyl)thiazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)-piperidine

Base Information

Chemical Name:4-(5-(4-Fluorophenyl)-4-(4-methoxyphenyl)thiazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)-piperidine
CAS No.:951743-67-2
Molecular Formula:C₂₃H₂₄FN₃O₃S
Molecular Weight:441.526
Hs Code.:

Synonyms:4-(5-(4-Fluorophenyl)-4-(4-methoxyphenyl)thiazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)-piperidine

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Chemical Property of 4-(5-(4-Fluorophenyl)-4-(4-methoxyphenyl)thiazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)-piperidine

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Technology Process of 4-(5-(4-Fluorophenyl)-4-(4-methoxyphenyl)thiazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)-piperidine

There total 4 articles about 4-(5-(4-Fluorophenyl)-4-(4-methoxyphenyl)thiazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₀ClFN₂O₂S

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 951743-67-2
4-(5-(4-Fluorophenyl)-4-(4-methoxyphenyl)thiazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)-piperidine

Guidance literature:: With triethylamine; In tetrahydrofuran; at 50 ℃; for 4.5h;

Reference yield:

: 214834-18-1
tert-butyl 4-carbamothioylpiperidine-1-carboxylate

: 951743-67-2
4-(5-(4-Fluorophenyl)-4-(4-methoxyphenyl)thiazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 4 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: triethylamine / tetrahydrofuran / 1 h / 0 °C

4: triethylamine / tetrahydrofuran / 4.5 h / 50 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: C₂₆H₂₉FN₂O₃S

: 951743-67-2
4-(5-(4-Fluorophenyl)-4-(4-methoxyphenyl)thiazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: triethylamine / tetrahydrofuran / 1 h / 0 °C

3: triethylamine / tetrahydrofuran / 4.5 h / 50 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;