4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-(pent-4-enoyloxy)ethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate

Base Information

• Chemical Name: 4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-(pent-4-enoyloxy)ethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate
• CAS No.: 1160108-88-2
• Molecular Formula: C₂₅H₃₂N₂O₇
• Molecular Weight: 472.538
• Mol file: 1160108-88-2.mol

Synonyms:4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-(pent-4-enoyloxy)ethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate

Chemical Property of 4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-(pent-4-enoyloxy)ethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-(pent-4-enoyloxy)ethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate

There total 1 articles about 4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-(pent-4-enoyloxy)ethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

pent-4-enoyl chloride (39716-58-0) + 4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-hydroxyethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate (1160108-87-1) → 4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-(pent-4-enoyloxy)ethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate (1160108-88-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.200801193

Reference yield:

4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-(pent-4-enoyloxy)ethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate (1160108-88-2) → 4-nitrobenzyl (4Z,10R,11S,13R)-10-methyl-8,12-dioxo-13-propyl-9-oxa-1-azabicyclo[9.1.1]tridec-4-ene 2-carboxylate + 4-nitrobenzyl (4E,10R,11S,13R)-10-methyl-8,12-dioxo-13-propyl-9-oxa-1-azabicyclo[9.1.1]tridec-4-ene 2-carboxylate (1160220-01-8)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; C₄H₁₀*C₉H₂₂O₄Ti; In toluene; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.200801193

upstream raw materials:

pent-4-enoyl chloride

4-nitrobenzyl 2-{(3S,4R)-3-[(1R)-1-hydroxyethyl]-2-oxo-4-propyl-1-azetidinyl}pent-4-enoate

Downstream raw materials:

4-nitrobenzyl (4E,10R,11S,13R)-10-methyl-8,12-dioxo-13-propyl-9-oxa-1-azabicyclo[9.1.1]tridec-4-ene 2-carboxylate