39716-58-0Relevant articles and documents
Degenerative xanthate transfer to olefins under visible-light photocatalysis
Kaga, Atsushi,Wu, Xiangyang,Yi, Joel,Lim, Jie,Hayashi, Hirohito,Lu, Yunpeng,Yeow, Edwin K.L.,Chiba, Shunsuke
, p. 3047 - 3058 (2018)
The degenerative transfer of xanthates to olefins is enabled by the iridium-based photocatalyst [Ir{dF(CF3)ppy}2(dtbbpy)](PF6) under blue LED light irradiation. Detailed mechanistic investigations through kinetics and phot
Synthesis, characterization and conducting properties of sulfonated poly and co-polymer of cholesteryl 4-pentenoate with 1-hexene
Hoque, Samiul,Dass, Narendra Nath,Bhattcharyya, Krishna Gopal,Sarma, Neelotpal Sen
, p. 450 - 457 (2013)
This manuscript reports the synthesis of the liquid crystalline (LC) monomer cholesteryl 4-pentenoate and its sulfone and co-polysulfone with 1-hexene. The polymers were characterized by IR, 1H-NMR, differential scanning calorimetry and thermogravimetric analysis techniques. The LC phases were observed under a hot stage fitted with a polarizing optical microscope. The elemental analysis for the sulfone group was done by SEM (energy dispersive X-ray analysis) analysis. The amount of elemental sulfur present in polysulfone and co-polysulfone is 4.95 weight (%) and 5.71weight (%), respectively. The molecular weights were determined by Gel Permeation Chromatography, using tetrahydrofuran as the solvent. The number average molecular weight of the polysulfone is 5950 g/mol. The molecular weights of the co-polysulfones were found to be higher than the polysulfone. From I-V characteristics, the breaking voltage for the polymers was computed to be around 5 V. The conductivity of the polysulfone and co-polysulfones increases with increasing temperature.
Total synthesis of phenanthroindolizidine alkaloids through an amidyl radical cascade/rearrangement reaction
Han, Guifang,Liu, Yuxiu,Wang, Qingmin
, p. 5334 - 5337 (2013)
A short and general synthesis of the phenanthroindolizidine alkaloids is reported, featuring an unusual amidyl radical 5-exo/5-exo/rearrangement cascade of a xanthate precursor. Second, using an amidyl radical 5-exo/6-endo cascade to synthesize a phenanth
Synthesis and Biological Evaluation of Endocannabinoid Uptake Inhibitors Derived from WOBE437
M?der, Patrick,Bartholom?us, Ruben,Nicolussi, Simon,Baumann, Alice,Weis, Melanie,Chicca, Andrea,Rau, Mark,Sim?o, Ana Catarina,Gertsch, Jürg,Altmann, Karl-Heinz
supporting information, p. 145 - 154 (2020/06/02)
WOBE437 ((2E,4E)-N-(3,4-dimethoxyphenethyl)dodeca-2,4-dienamide, 1) is a natural product-derived, highly potent inhibitor of endocannabinoid reuptake. In this study, we synthesized almost 80 analogues of 1 with different types of modifications in the dodecadienoyl domain as well as the dimethoxyphenylethyl head group, and we investigated their effects on anandamide uptake into U937 cells. Intriguingly, none of these analogues was a more potent inhibitor of anandamide uptake than WOBE437 (1). At the same time, a number of WOBE437 variants exhibited potencies in the sub-100 nM range, with high selectivity over inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase; two compounds were virtually equipotent with 1. Interestingly, profound activity differences were observed between analogues in which either of the two methoxy substituents in the head group had been replaced by the same bulkier alkoxy group. Some of the compounds described here could be interesting departure points for the development of potent endocannabinoid uptake inhibitors with more drug-like properties.
Electrodimerization ofN-Alkoxyamides for the Synthesis of Hydrazines
Nasier, Abudulajiang,Chang, Xihao,Guo, Chang
, p. 16068 - 16076 (2021/09/18)
An efficient and valuable N-N dimerization reaction ofN-alkoxyamides is reported under undivided electrolytic conditions. This electrochemical strategy provides a powerful way to access a wide range of advanced, highly functionalized hydrazines. Remarkably, anN-centered radical generated from the cleavage of the N-H bond under electrolytic conditions plays a crucial role in this transformation. Furthermore, variousN-alkoxyamides bearing different substituents are suitable in this transformation, furnishing the corresponding hydrazines in up to 92% yield.
Redox-Neutral Nickel(II) Catalysis: Hydroarylation of Unactivated Alkenes with Arylboronic Acids
Feng, Wang,Liu, Tao,Wang, Dao-Ming,Wang, Peng,Wu, Yichen
supporting information, p. 20399 - 20404 (2020/09/09)
Reported here is the discovery of a redox-neutral NiII/NiII catalytic cycle which is capable of the linear-selective hydroarylation of unactivated alkenes with arylboronic acids for the first time. This novel catalytic cycle, enabled