6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol

Base Information

Chemical Name:6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol
CAS No.:551934-77-1
Molecular Formula:C₃₃H₃₂N₂O₂
Molecular Weight:488.629
Hs Code.:

Synonyms:6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol

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Chemical Property of 6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol

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Technology Process of 6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol

There total 3 articles about 6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 551934-85-1
6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan

: 551934-77-1
6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol

Guidance literature:: With 1-thiopropane; sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 120 ℃; for 4h;
DOI:10.1002/hlca.200390080

Reference yield:

: 59-88-1
phenylhydrazine hydrochloride

: 551934-77-1
6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 25 percent / aq.HCl / acetic acid / 4 h / Heating

2: 77 percent / propane-1-thiol; NaH / hexamethylphosphoric acid triamide / 4 h / 120 °C

With hydrogenchloride; 1-thiopropane; sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetic acid;
DOI:10.1002/hlca.200390080

Reference yield:

: 551934-82-8
C₂₈H₃₁NO₃

: 551934-77-1
6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 25 percent / aq.HCl / acetic acid / 4 h / Heating

2: 77 percent / propane-1-thiol; NaH / hexamethylphosphoric acid triamide / 4 h / 120 °C

With hydrogenchloride; 1-thiopropane; sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetic acid;
DOI:10.1002/hlca.200390080