6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan

Base Information

• Chemical Name: 6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan
• CAS No.: 551934-85-1
• Molecular Formula: C₃₄H₃₄N₂O₂
• Molecular Weight: 502.656
• Mol file: 551934-85-1.mol

Synonyms:6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan

Chemical Property of 6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan

There total 1 articles about 6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

phenylhydrazine hydrochloride (59-88-1) + C28H31NO3 (551934-82-8) → 6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan (551934-85-1)

Guidance literature:

With hydrogenchloride; In acetic acid; for 4h; Heating;

DOI:10.1002/hlca.200390080

Reference yield: 77.0%

6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan (551934-85-1) → 6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol (551934-77-1)

Guidance literature:

With 1-thiopropane; sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 120 ℃; for 4h;

DOI:10.1002/hlca.200390080

Reference yield:

6,7-didehydro-4,5α-epoxy-3-methoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan (551934-85-1) → 6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[3-phenylpropyl]indolo[2',3':6,7]morphinan-3-ol

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / propane-1-thiol; NaH / hexamethylphosphoric acid triamide / 4 h / 120 °C

2: 90 percent / H₂ / Pd/C / ethyl acetate / 24 h

With 1-thiopropane; hydrogen; sodium hydride; palladium on activated charcoal; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethyl acetate;

DOI:10.1002/hlca.200390080

upstream raw materials:

phenylhydrazine hydrochloride

C₂₈H₃₁NO₃

Downstream raw materials:

6,7-didehydro-4,5α-epoxy-5,17-dimethyl-14β-[(2E)-3-phenylprop-2-enyl]indolo[2',3':6,7]morphinan-3-ol