1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate

Base Information

• Chemical Name: 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate
• CAS No.: 1384896-85-8
• Molecular Formula: C₁₃H₁₂O₃S
• Molecular Weight: 248.302
• Mol file: 1384896-85-8.mol

Synonyms:1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate

Chemical Property of 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate

There total 6 articles about 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(2-methyl-5-phenylthiophen-3-yl)ethan-1-one (40932-63-6) → 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate (1384896-85-8)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; water; for 24h; Reflux;

DOI:10.1002/anie.201506269

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate (1384896-85-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran / 24 h / 60 °C

1.2: 20 °C

2.1: tin(IV) chloride / toluene

3.1: selenium(IV) oxide; water / 1,4-dioxane / Reflux

With 2,2,6,6-tetramethyl-piperidine; selenium(IV) oxide; ethylmagnesium bromide; water; tin(IV) chloride; In tetrahydrofuran; 1,4-dioxane; toluene;

DOI:10.1002/anie.201912921

Reference yield:

2-Methylthiophene (554-14-3) → 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate (1384896-85-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran / 24 h / 60 °C

1.2: 20 °C

2.1: tin(IV) chloride / toluene

3.1: selenium(IV) oxide; water / 1,4-dioxane / Reflux

With 2,2,6,6-tetramethyl-piperidine; selenium(IV) oxide; ethylmagnesium bromide; water; tin(IV) chloride; In tetrahydrofuran; 1,4-dioxane; toluene;

DOI:10.1002/anie.201912921

upstream raw materials:

2-methyl-5-phenylthiophene

1-(2-methyl-5-phenylthiophen-3-yl)ethan-1-one

bromobenzene

2-Methylthiophene

Downstream raw materials:

1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone

1,2-bis-(2’-methyl-5’-phenylthien-3’-yl)-ethanedione

4,5-bis(2-methyl-5-phenylthiophen-3-yl)-1H-imidazole