1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone

Base Information

• Chemical Name: 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone
• CAS No.: 1054613-79-4
• Molecular Formula: C₂₄H₂₀O₂S₂
• Molecular Weight: 404.554
• Mol file: 1054613-79-4.mol

Synonyms:1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone

Chemical Property of 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone

There total 7 articles about 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-methyl-5-phenylthiophene (5069-26-1) + 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-glyoxal monohydrate (1384896-85-8) → 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone (1054613-79-4)

Guidance literature:

With tin(IV) chloride; In toluene;

DOI:10.1002/anie.201912921 DOI:10.1021/jacs.0c11894

Reference yield: 70.0%

2-methyl-5-phenylthiophene (5069-26-1) + 1-(2-methyl-5-phenylthiophen-3-yl)ethan-1-one (40932-63-6) → 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone (1054613-79-4)

Guidance literature:

1-(2-methyl-5-phenylthiophen-3-yl)ethan-1-one; With selenium(IV) oxide; In 1,4-dioxane; water; for 48h; Inert atmosphere; Reflux;

2-methyl-5-phenylthiophene; With tin(IV) chloride; In toluene; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ja304067k

Reference yield: 40.0%

2-methyl-5-phenylthiophene-3-carboxaldehyde (40968-74-9) → 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone (1054613-79-4)

Guidance literature:

With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; diisopropylamine; In ethanol; for 3h; Inert atmosphere; Reflux;

DOI:10.1002/anie.200800869

upstream raw materials:

2-methyl-5-phenylthiophene-3-carboxaldehyde

2-methyl-5-phenylthiophene

1-(2-methyl-5-phenylthiophen-3-yl)ethan-1-one

bromobenzene

Downstream raw materials:

4,5-bis(2'-methyl-5'-phenylthien-3'-yl)-2-phenyl-1,3,2-dioxaborole

1,2-bis-(2'-methyl-5'-phenylthien-3'-yl)-2-13C-imidazole

1,2-bis-(2’-methyl-5’-phenylthien-3’-yl)-ethanedione

4,5-bis(2-methyl-5-phenylthiophen-3-yl)-1H-imidazole