(S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

Base Information

Chemical Name:(S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one
CAS No.:406215-57-4
Molecular Formula:C₂₁H₂₅NO₆
Molecular Weight:387.433
Hs Code.:

Synonyms:(S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

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Chemical Property of (S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

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Technology Process of (S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

There total 15 articles about (S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 406215-98-3
(S)-(-)-3-[2-(2-benzyloxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

: 406215-57-4
(S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 8h;
DOI:10.1021/jo010988v

Reference yield: 78.0%

: 406215-71-2
4-methyl-benzenesulfinic acid [1-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,5-dimethoxy-phenyl}-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide

: 406215-57-4
(S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: With lithium hydroxide; In methanol; for 8h; Heating;
DOI:10.1021/jo010988v

Reference yield:

: 494-99-5
1,2-dimethoxy-4-methylbenzene

: 406215-57-4
(S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / N-bromosuccinimide / CHCl₃ / 4 h / Heating

2.1: 90 percent / dimethylformamide / 16 h / 120 °C

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 68 percent / tetrahydrofuran / 0.5 h / -78 °C

4.1: 78 percent / LiOH / methanol / 8 h / Heating

With lithium hydroxide; N-Bromosuccinimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo010988v