3-BROMO-4-METHOXY-PYRIDINE

Base Information

• Chemical Name: 3-BROMO-4-METHOXY-PYRIDINE
• CAS No.: 82257-09-8
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.024
• Hs Code.: 2933399090
• Mol file: 82257-09-8.mol

Synonyms:3-Bromo-4-methoxypyridine;pyridine, 3-bromo-4-methoxy-;

Chemical Property of 3-BROMO-4-METHOXY-PYRIDINE

Chemical Property:

• Vapor Pressure: 0.227mmHg at 25°C
• Refractive Index: 1.542
• Boiling Point: 214.5 °C at 760 mmHg
• PKA: 4.19±0.18(Predicted)
• Flash Point: 83.5 °C
• PSA: 22.12000
• Density: 1.53 g/cm³
• LogP: 1.85270
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Water Solubility.: Slightly soluble in water (9.8 g/L).

Purity/Quality:

98%, ^*data from raw suppliers

3-Bromo-4-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-4-methoxypyridine acid is used as a intermediate for pharmaceutical and organic synthesis.

Technology Process of 3-BROMO-4-METHOXY-PYRIDINE

There total 7 articles about 3-BROMO-4-METHOXY-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-bromo-4-chloropyridine (36953-42-1) + sodium methylate (124-41-4) → bromo-3 methoxy-4 pyridine (82257-09-8)

Guidance literature:

In methanol; for 20h; Heating;

Reference yield: 67.0%

4-methoxypyridine (620-08-6,1232006-56-2) → bromo-3 methoxy-4 pyridine (82257-09-8)

Guidance literature:

With bromocyane; phenyllithium; In tetrahydrofuran; at -70 ℃; for 2h;

DOI:10.1016/S0040-4020(01)81920-7

Reference yield:

pyridin-3-ylamine (462-08-8) → bromo-3 methoxy-4 pyridine (82257-09-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / HBr/Cu₂Br₂, NaNO₂

2: 90 percent / H₂O₂, CH₃CO₂H

3: 94 percent / HNO₃, H₂SO₄

4: 78 percent / PCl₃ / CHCl₃

5: 79 percent / methanol / 20 h / Heating

With copper(I) bromide; sulfuric acid; hydrogen bromide; dihydrogen peroxide; nitric acid; acetic acid; sodium nitrite; phosphorus trichloride; In methanol; chloroform;

upstream raw materials:

4-methoxypyridine

3-bromo-4-chloropyridine

sodium methylate

pyridin-3-ylamine

Downstream raw materials:

2-amino-5-(propan-2-yl)pyridine

(4-methoxypyridin-3-yl)boronic acid

C₁₃H₁₆ClNO₂

4-methoxynicotinaldehyde