4-Fluoro-2-methoxypyridine

Base Information

• Chemical Name: 4-Fluoro-2-methoxypyridine
• CAS No.: 96530-81-3
• Molecular Formula: C6H6FNO
• Molecular Weight: 127.118
• Hs Code.: 2933399090
• Mol file: 96530-81-3.mol

Synonyms:4-Fluoro-2-methoxypyridine;NSC 361062;

Chemical Property of 4-Fluoro-2-methoxypyridine

Chemical Property:

• Vapor Pressure: 11.1mmHg at 25°C
• Refractive Index: 1.471
• Boiling Point: 131.9 °C at 760 mmHg
• PKA: 2.28±0.10(Predicted)
• Flash Point: 33.6 °C
• PSA: 22.12000
• Density: 1.146 g/cm³
• LogP: 1.22930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

4-Fluoro-2-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-2-methoxypyridine

There total 3 articles about 4-Fluoro-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-4-nitropyridine N-oxide (14395-39-2) → 4-fluoro-2-methoxypyridine (96530-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Fe / acetic acid

2: NaNO₂, 48percent fluoroboric acid / 1) 0 deg, 45 min, 2) 0 deg C - RT, 30 min, 30 - 35 deg C, 30 min

With tetrafluoroboric acid; iron; sodium nitrite; In acetic acid;

DOI:10.1002/jhet.5570220136

Reference yield:

4-amino-2-methoxypyridine (20265-39-8) → 4-fluoro-2-methoxypyridine (96530-81-3)

Guidance literature:

With tetrafluoroboric acid; sodium nitrite; Yield given. Multistep reaction; 1) 0 deg, 45 min, 2) 0 deg C - RT, 30 min, 30 - 35 deg C, 30 min;

DOI:10.1002/jhet.5570220136

Reference yield:

4-Amino-2-chloropyridine (14432-12-3) + sodium methylate (124-41-4) → 4-fluoro-2-methoxypyridine (96530-81-3)

Guidance literature:

4-Amino-2-chloropyridine; sodium methylate; With copper;

With tetrafluoroboric acid; sodium nitrite;

DOI:10.1055/s-0030-1259006

upstream raw materials:

4-amino-2-methoxypyridine

2-methoxy-4-nitropyridine N-oxide

4-Amino-2-chloropyridine

sodium methylate

Downstream raw materials:

4-fluoro-1,2-dihydropyridin-2-one

4-(3-iodo-1H-pyrazol-1-yl)-2-methoxypyridine

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