1-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-4-methanesulfonyl-piperazine

Base Information

Chemical Name:1-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-4-methanesulfonyl-piperazine
CAS No.:1404120-46-2
Molecular Formula:C₁₈H₂₈BFN₂O₄S
Molecular Weight:398.307
Hs Code.:

Synonyms:1-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-4-methanesulfonyl-piperazine

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Chemical Property of 1-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-4-methanesulfonyl-piperazine

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Technology Process of 1-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-4-methanesulfonyl-piperazine

There total 3 articles about 1-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-4-methanesulfonyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1371127-04-6
1-(4-Bromo-2-fluoro-benzyl)-4-methanesulfonyl-piperazine

: 73183-34-3
bis(pinacol)diborane

: 1404120-46-2
1-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-4-methanesulfonyl-piperazine

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 100 ℃; for 6h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1404120-46-2
1-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-4-methanesulfonyl-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 18 h / 40 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 6 h / 100 °C / Inert atmosphere

With potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; acetonitrile;

Reference yield:

: 55276-43-2
4-methanesulfonylpiperazine

: 1404120-46-2
1-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-4-methanesulfonyl-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 18 h / 40 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 6 h / 100 °C / Inert atmosphere

With potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; acetonitrile;