6-chloro-4-((1S,2S)-2,3-dihydroxy-1-phenylpropylamino)-N-methylnicotinamide

Base Information

Chemical Name:6-chloro-4-((1S,2S)-2,3-dihydroxy-1-phenylpropylamino)-N-methylnicotinamide
CAS No.:1609545-77-8
Molecular Formula:C₁₆H₁₈ClN₃O₃
Molecular Weight:335.79
Hs Code.:

Synonyms:6-chloro-4-((1S,2S)-2,3-dihydroxy-1-phenylpropylamino)-N-methylnicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-4-((1S,2S)-2,3-dihydroxy-1-phenylpropylamino)-N-methylnicotinamide

Chemical Property:

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Technology Process of 6-chloro-4-((1S,2S)-2,3-dihydroxy-1-phenylpropylamino)-N-methylnicotinamide

There total 4 articles about 6-chloro-4-((1S,2S)-2,3-dihydroxy-1-phenylpropylamino)-N-methylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609530-95-1
4,6-dichloro-N-methylnicotinamide

: (2S,3S)-3-amino-3-phenylpropane-1,2-diol

: 1609545-77-8
6-chloro-4-((1S,2S)-2,3-dihydroxy-1-phenylpropylamino)-N-methylnicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 120 ℃; for 3h;
DOI:10.1016/j.bmcl.2017.09.029

Reference yield:

: 73027-79-9
4,6-dichloro-nicotinic acid

: 1609545-77-8
6-chloro-4-((1S,2S)-2,3-dihydroxy-1-phenylpropylamino)-N-methylnicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide

2: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2017.09.029

Reference yield:

: 65973-52-6
methyl 4,6-dichloropyridine-3-carboxylate

: 1609545-77-8
6-chloro-4-((1S,2S)-2,3-dihydroxy-1-phenylpropylamino)-N-methylnicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / ethanol / 4 h / 22 °C

2: oxalyl dichloride; N,N-dimethyl-formamide

3: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C

With oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2017.09.029