(2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile

Base Information

• Chemical Name: (2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile
• CAS No.: 863225-73-4
• Molecular Formula: C₃₆H₃₂ClF₃N₂O₃Si
• Molecular Weight: 661.195
• Mol file: 863225-73-4.mol

Synonyms:(2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile

Chemical Property of (2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile

There total 1 articles about (2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one (863225-72-3) + iodoacetonitrile (624-75-9) → (2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile (863225-73-4) + [3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile (863225-74-5) + [3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-cyanomethoxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1016/j.bmcl.2005.06.056

Reference yield: 72.0%

(2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile (863225-73-4) → {4-chloro-2-[3-(2-hydroxy-ethyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl]-phenoxy}-acetonitrile

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.06.056

Reference yield:

(2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile (863225-73-4) → 2-(2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetamide

Guidance literature:

With sodium peroxide; dihydrogen peroxide; In methanol;

DOI:10.1016/j.bmcl.2005.06.056

upstream raw materials:

3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one

iodoacetonitrile