863225-72-3

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 275375-69-4 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-2(1H)-quinolinone 

Downstream Products

• 863225-73-4 (2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile 
• 863225-74-5 [3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile 
• 721918-21-4 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate 
• 863225-76-7 acetic acid 2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-1-cyanomethyl-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenyl ester 
• 930780-16-8 4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one 
• 721918-22-5 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate 
• 930780-25-9 C₂₂H₂₁ClF₃NO₅ 

Relevant academic research and scientific papers

Atropisomeric 3-(β-hydroxyethyl)-4-arylquinolin-2-ones as maxi-K potassium channel openers

The synthesis of a series of 3-β-hydroxyethyl-4-arylquinolin-2-ones is described. These compounds contain hydrophilic and hydrophobic substituents ortho to the phenolic OH in the C ring of the quinolinone. Electrophysiological evaluation of the panel of c

ATROPISOMERS OF 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES

Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives having the general formula wherein R, R?1?, R?2?, R?3?, R?4? and R?5?, are as defined herein, or a non-toxic pharmaceutically acceptable salt, solvate or prodrug thereof. The atropisomers can