2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzoisoindole-1,3(2H)-dione

Base Information

Chemical Name:2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzoisoindole-1,3(2H)-dione
CAS No.:82167-66-6
Molecular Formula:C₂₂H₂₁NO₆
Molecular Weight:395.412
Hs Code.:

2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzo<f>isoindole-1,3(2H)-dione

Synonyms:2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzoisoindole-1,3(2H)-dione

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Chemical Property of 2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzoisoindole-1,3(2H)-dione

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Technology Process of 2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzoisoindole-1,3(2H)-dione

There total 5 articles about 2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzoisoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 941-69-5
N-phenyl-maleimide

: 2,3-dimethylene-4-trimethylsilylbutan-1-ol

: 762-42-5
dimethyl acetylenedicarboxylate

: 82167-66-6
2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzoisoindole-1,3(2H)-dione

Guidance literature:: N-phenyl-maleimide; 2,3-dimethylene-4-trimethylsilylbutan-1-ol; In 1,2-dichloro-ethane; at 100 ℃; for 0.75h; Inert atmosphere; Sealed tube;

With zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; at 70 ℃; for 0.25h; Inert atmosphere;

dimethyl acetylenedicarboxylate; In diethyl ether; 1,2-dichloro-ethane; at 100 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jacs.5b04091

Reference yield:

: 82167-48-4
2,3-bis<(trimethyksilyl)methyl>-1,3-butadiene

: 82167-66-6
2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzoisoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / hydroquinone / toluene / Heating

2: NBS, propylene oxide / tetrahydrofuran / 1.) -100 deg C, 10 min, 2.) -78 deg C, 1 h

3: tetrahydrofuran / -78 deg C to room temperature, overnight

With N-Bromosuccinimide; hydroquinone; methyloxirane; In tetrahydrofuran; toluene;
DOI:10.1021/ja00379a066

Reference yield:

: 82167-49-5
4,5-Bis-trimethylsilanylmethyl-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester

: 82167-66-6
2-phenyl-6,7-dicarbomethoxy-3a,4,5,8,9,9a-hexahydro-1H-benzoisoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: NBS, propylene oxide / tetrahydrofuran / 1.) -100 deg C, 10 min, 2.) -78 deg C, 1 h

2: tetrahydrofuran / -78 deg C to room temperature, overnight

With N-Bromosuccinimide; methyloxirane; In tetrahydrofuran;
DOI:10.1021/ja00379a066