tert-butyl 2-{[4-(tert-butyl)cyclohex-1-enyl]carbonyl}indol-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-{[4-(tert-butyl)cyclohex-1-enyl]carbonyl}indol-1-carboxylate
CAS No.:205310-48-1
Molecular Formula:C₂₄H₃₁NO₃
Molecular Weight:381.515
Hs Code.:

Synonyms:tert-butyl 2-{[4-(tert-butyl)cyclohex-1-enyl]carbonyl}indol-1-carboxylate

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Chemical Property of tert-butyl 2-{[4-(tert-butyl)cyclohex-1-enyl]carbonyl}indol-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 2-{[4-(tert-butyl)cyclohex-1-enyl]carbonyl}indol-1-carboxylate

There total 3 articles about tert-butyl 2-{[4-(tert-butyl)cyclohex-1-enyl]carbonyl}indol-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 201230-82-2
carbon monoxide

: 77412-96-5
1-trifluoromethanesulfonyloxy-4-t-butylcyclohexene

: lithium triethyl(1-tert-butoxycarbonylindol-2-yl)borate

: 205310-48-1
tert-butyl 2-{[4-(tert-butyl)cyclohex-1-enyl]carbonyl}indol-1-carboxylate

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 60 ℃; for 20h; under 7600 Torr;
DOI:10.3987/COM-00-9008

Reference yield:

: 75400-67-8
indole-1-carboxylic acid tert-butyl ester

: 205310-48-1
tert-butyl 2-{[4-(tert-butyl)cyclohex-1-enyl]carbonyl}indol-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tert-BuLi / tetrahydrofuran

2: 73 percent / PdCl₂(PPh₃)2 / tetrahydrofuran / 20 h / 60 °C / 7600 Torr

With tert.-butyl lithium; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran;
DOI:10.3987/COM-00-9008

Reference yield:

: 201230-82-2
carbon monoxide

: 77412-96-5
1-trifluoromethanesulfonyloxy-4-t-butylcyclohexene

: 75400-67-8
indole-1-carboxylic acid tert-butyl ester

: 205310-48-1
tert-butyl 2-{[4-(tert-butyl)cyclohex-1-enyl]carbonyl}indol-1-carboxylate

Guidance literature:: With n-butyllithium; triethyl borane; bis-triphenylphosphine-palladium(II) chloride; Yield given. Multistep reaction; 1.) THF, -20 deg C, 20 min; 2.) THF, 60 deg C, 60 atm, 60 h;
DOI:10.3987/COM-97-7940