2-Amino-3-chloro-5-nitro-6-picoline

Base Information

• Chemical Name: 2-Amino-3-chloro-5-nitro-6-picoline
• CAS No.: 56960-81-7
• Molecular Formula: C₆H₆ClN₃O₂
• Molecular Weight: 187.586
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID00482443
• Wikidata: Q82318763
• Mol file: 56960-81-7.mol

Synonyms:2-Amino-3-chloro-5-nitro-6-picoline;56960-81-7;3-chloro-6-methyl-5-nitropyridin-2-amine;3-chloro-6-methyl-5-nitro-2-pyridinamine;DTXSID00482443;AKOS006328977;CS-0375661;FT-0652982;3-chloranyl-6-methyl-5-nitro-pyridin-2-amine;A831256

Chemical Property of 2-Amino-3-chloro-5-nitro-6-picoline

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.637
• Boiling Point: 313.197 °C at 760 mmHg
• Flash Point: 143.217 °C
• PSA: 84.73000
• Density: 1.501g/cm³
• LogP: 2.63820
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 187.0148541
• Heavy Atom Count: 12
• Complexity: 184

Purity/Quality:

98%Min ^*data from raw suppliers

3-Chloro-6-methyl-5-nitro-pyridin-2-ylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=C(C=C1[N+](=O)[O-])Cl)N

Technology Process of 2-Amino-3-chloro-5-nitro-6-picoline

There total 4 articles about 2-Amino-3-chloro-5-nitro-6-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methyl-5-nitro-2-pyridinamine (22280-62-2) → 2-Amino-3-chlor-6-methyl-5-nitro-pyridin (56960-81-7)

Guidance literature:

With chlorine; acetic acid;

DOI:10.1021/ja01193a016

Reference yield:

α-picoline (109-06-8) → 2-Amino-3-chlor-6-methyl-5-nitro-pyridin (56960-81-7)

Guidance literature:

Multi-step reaction with 3 steps

1: liquid NH₃; xylene; Fe(NO₃)3

2: concentrated H₂SO₄; concentrated HNO₃

3: acetic acid; chlorine

With sulfuric acid; ammonia; nitric acid; chlorine; acetic acid; ferric nitrate; xylene;

DOI:10.1021/ja01193a016

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 2-Amino-3-chlor-6-methyl-5-nitro-pyridin (56960-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated H₂SO₄; concentrated HNO₃

2: acetic acid; chlorine

With sulfuric acid; nitric acid; chlorine; acetic acid;

DOI:10.1021/ja01193a016

upstream raw materials:

6-methyl-5-nitro-2-pyridinamine

α-picoline

2-Amino-6-methylpyridine