C₂₂H₂₀N₄O₈S₂

Base Information

• Chemical Name: C₂₂H₂₀N₄O₈S₂
• CAS No.: 1359745-98-4
• Molecular Formula: C₂₂H₂₀N₄O₈S₂
• Molecular Weight: 532.555
• Mol file: 1359745-98-4.mol

Synonyms:C₂₂H₂₀N₄O₈S₂

Chemical Property of C₂₂H₂₀N₄O₈S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀N₄O₈S₂

There total 1 articles about C₂₂H₂₀N₄O₈S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

2,4-dinitrothiophenol (2218-96-4) + para-methoxybenzyl (6R,7R)-7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride → C22H20N4O8S2 (1359745-98-4)

Guidance literature:

With 4-methyl-morpholine; triethylamine; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1002/asia.201100647

Reference yield: 32.0%

BOC-glycine (4530-20-5) + C22H20N4O8S2 (1359745-98-4) → C29H31N5O11S2 (1359746-00-1)

Guidance literature:

BOC-glycine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

C₂₂H₂₀N₄O₈S₂; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 30h;

DOI:10.1002/asia.201100647

Reference yield:

C22H20N4O8S2 (1359745-98-4) → C2HF3O2*C16H15N5O8S2 (1381975-84-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 30 h / 0 - 20 °C

2.1: methyl-phenyl-thioether / dichloromethane / 18 h / 0 °C

With methyl-phenyl-thioether; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/asia.201100647

upstream raw materials:

2,4-dinitrothiophenol

Downstream raw materials:

C₂₉H₃₁N₅O₁₁S₂

C₂HF₃O₂*C₁₆H₁₅N₅O₈S₂

C₂₆H₁₉N₅O₁₂S₂