(1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-(methylsulfonyl)pyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:(1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-(methylsulfonyl)pyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1430745-86-0
Molecular Formula:C₂₄H₃₆N₂O₆S
Molecular Weight:480.626
Hs Code.:

Synonyms:(1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-(methylsulfonyl)pyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Chemical Property of (1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-(methylsulfonyl)pyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of (1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-(methylsulfonyl)pyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 6 articles about (1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-(methylsulfonyl)pyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.9%

: 1430746-11-4
(1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-bromopyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 20277-69-4
sodium methansulfinate

: 1430745-86-0
(1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-(methylsulfonyl)pyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With copper(I) trifluoromethanesulfonate benzene; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 120 ℃;

Reference yield:

: 1430746-08-9
(1R,3s,5S)-tert-butyl 3-(4-hydroxyphenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1430745-86-0
(1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-(methylsulfonyl)pyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetraborate decahydrate; palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 24 h / 80 °C / 9000.9 Torr / Autoclave

2: potassium tert-butylate / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

3: copper(I) trifluoromethanesulfonate benzene; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 120 °C

With copper(I) trifluoromethanesulfonate benzene; sodium tetraborate decahydrate; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; N,N`-dimethylethylenediamine; In tetrahydrofuran; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1430747-30-0
(1R,3s,5S)-tert-butyl 3-((1r,4R)-4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1430745-86-0
(1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(5-(methylsulfonyl)pyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2: copper(I) trifluoromethanesulfonate benzene; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 120 °C

With copper(I) trifluoromethanesulfonate benzene; potassium tert-butylate; N,N`-dimethylethylenediamine; In tetrahydrofuran; dimethyl sulfoxide;