3-Amino-6-bromo-2,4-dichloropyridine

Base Information

• Chemical Name: 3-Amino-6-bromo-2,4-dichloropyridine
• CAS No.: 237435-16-4
• Molecular Formula: C5H3BrCl2N2
• Molecular Weight: 241.902
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID00445437
• Wikidata: Q82263836
• Mol file: 237435-16-4.mol

Synonyms:3-Amino-6-bromo-2,4-dichloropyridine;237435-16-4;6-bromo-2,4-dichloropyridin-3-amine;3-Pyridinamine,6-bromo-2,4-dichloro-;6-BROMO-2,4-DICHLORO-3-PYRIDINAMINE;SCHEMBL4663299;DTXSID00445437;MNMVXSHYBWKOIG-UHFFFAOYSA-N;MFCD09750300;AKOS015835540;AB51382;DS-2604;A4951;CS-0045914;FT-0658764;6-BROMO-2,4-DICHLORO-3-AMINOPYRIDINE;C74226;J-400773

Chemical Property of 3-Amino-6-bromo-2,4-dichloropyridine

Chemical Property:

• Boiling Point: 301.229 °C at 760 mmHg
• PKA: -2.02±0.10(Predicted)
• Flash Point: 135.979 °C
• PSA: 38.91000
• Density: 1.934±0.06 g/cm3(Predicted)
• LogP: 3.31430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 239.88567
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-6-bromo-2,4-dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=C(N=C1Br)Cl)N)Cl

Technology Process of 3-Amino-6-bromo-2,4-dichloropyridine

There total 4 articles about 3-Amino-6-bromo-2,4-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4-dichloropyridin-3-ylamine (173772-63-9) → 6-bromo-2,4-dichloropyridin-3-ylamine (237435-16-4)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

DOI:10.1021/jm000269t

Reference yield:

3-deazauracil (626-03-9,84719-31-3) → 6-bromo-2,4-dichloropyridin-3-ylamine (237435-16-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / fuming HNO₃; conc. H₂SO₄ / 0.5 h / 0 °C

2: 80 percent / POCl₃ / 24 h / Heating

3: 90 percent / SnCl₂*2H₂O; conc. aq. HCl / diethyl ether / 20 °C

4: 90 percent / N-bromosuccinimide / dimethylformamide / 0.25 h / 0 °C

With hydrogenchloride; N-Bromosuccinimide; sulfuric acid; nitric acid; tin(ll) chloride; trichlorophosphate; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jm000269t

Reference yield:

2,4-dihydroxy-3-nitropyridine (89282-12-2) → 6-bromo-2,4-dichloropyridin-3-ylamine (237435-16-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / POCl₃ / 24 h / Heating

2: 90 percent / SnCl₂*2H₂O; conc. aq. HCl / diethyl ether / 20 °C

3: 90 percent / N-bromosuccinimide / dimethylformamide / 0.25 h / 0 °C

With hydrogenchloride; N-Bromosuccinimide; tin(ll) chloride; trichlorophosphate; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jm000269t

upstream raw materials:

2,4-dichloropyridin-3-ylamine

3-deazauracil

2,4-dihydroxy-3-nitropyridine

2,4-dichloro-3-nitro-pyridine

Downstream raw materials:

3-amino-2,4-dichloro-6-methylpyridine

7-chloro-5-methyl-2-phenylpyrrolo[3,2-b]pyridine

3-amino-4-chloro-6-methyl-2-(2-phenylethynyl)pyridine