(2R,3R)-3-ethyl-2-((S)-(3-fluorophenyl)((1R,2R)-2-hydroxy-1,2-diphenylethoxy)methyl)cyclohexanone

Base Information

Chemical Name:(2R,3R)-3-ethyl-2-((S)-(3-fluorophenyl)((1R,2R)-2-hydroxy-1,2-diphenylethoxy)methyl)cyclohexanone
CAS No.:1262388-91-9
Molecular Formula:C₂₉H₃₁FO₃
Molecular Weight:446.562
Hs Code.:

Synonyms:(2R,3R)-3-ethyl-2-((S)-(3-fluorophenyl)((1R,2R)-2-hydroxy-1,2-diphenylethoxy)methyl)cyclohexanone

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Chemical Property of (2R,3R)-3-ethyl-2-((S)-(3-fluorophenyl)((1R,2R)-2-hydroxy-1,2-diphenylethoxy)methyl)cyclohexanone

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Technology Process of (2R,3R)-3-ethyl-2-((S)-(3-fluorophenyl)((1R,2R)-2-hydroxy-1,2-diphenylethoxy)methyl)cyclohexanone

There total 4 articles about (2R,3R)-3-ethyl-2-((S)-(3-fluorophenyl)((1R,2R)-2-hydroxy-1,2-diphenylethoxy)methyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1262388-81-7
(4R,5R)-2-(3-fluorophenyl)-4,5-diphenyl-1,3-dioxolane

: 1262388-94-2
(R)-trimethyl(3-ethylcyclohex-1-enyloxy)silane

: 1262388-91-9
(2R,3R)-3-ethyl-2-((S)-(3-fluorophenyl)((1R,2R)-2-hydroxy-1,2-diphenylethoxy)methyl)cyclohexanone

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 ℃; for 4h; stereoselective reaction;
DOI:10.1016/j.tet.2010.10.048

Reference yield:

: 588-59-0
stilbene

: 1262388-91-9
(2R,3R)-3-ethyl-2-((S)-(3-fluorophenyl)((1R,2R)-2-hydroxy-1,2-diphenylethoxy)methyl)cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: AD-mix-β / tert-butyl alcohol / 72 h

2: toluene-4-sulfonic acid / toluene / Reflux; Dean-Stark

3: titanium tetrachloride / dichloromethane / 4 h / -78 °C

With AD-mix-β; titanium tetrachloride; toluene-4-sulfonic acid; In dichloromethane; toluene; tert-butyl alcohol; 3: |Mukaiyama Aldol Addition;
DOI:10.1016/j.tet.2010.10.048

Reference yield:

: 930-68-7
cyclohexenone

: 1262388-91-9
(2R,3R)-3-ethyl-2-((S)-(3-fluorophenyl)((1R,2R)-2-hydroxy-1,2-diphenylethoxy)methyl)cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(II) bis(trifluoromethanesulfonate); (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine / toluene; dichloromethane / 1 h / -40 °C / Inert atmosphere; Schlenk technique

1.2: -20 - 20 °C / Inert atmosphere; Schlenk technique

2.1: titanium tetrachloride / dichloromethane / 4 h / -78 °C

With titanium tetrachloride; copper(II) bis(trifluoromethanesulfonate); (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine; In dichloromethane; toluene; 2.1: |Mukaiyama Aldol Addition;
DOI:10.1016/j.tet.2010.10.048