Technology Process of (S)-5-benzyl-4,4'-dimethyl-1,2-dihydro-1,1'-biphenyl
There total 4 articles about (S)-5-benzyl-4,4'-dimethyl-1,2-dihydro-1,1'-biphenyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; caesium carbonate;
In
toluene;
at 110 ℃;
for 26h;
optical yield given as %ee;
enantiospecific reaction;
Inert atmosphere;
DOI:10.1002/anie.201103450
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C
2: hydrogenchloride / 1,4-dioxane; water / 12 h / 100 °C
3: (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; caesium carbonate / toluene / 26 h / 110 °C / Inert atmosphere
With
hydrogenchloride; (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; tetrabutyl ammonium fluoride; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; water; toluene;
DOI:10.1002/anie.201103450
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ammonia; potassium; tert-butyl alcohol / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
1.2: 1.08 h / -78 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C
3.1: hydrogenchloride / 1,4-dioxane; water / 12 h / 100 °C
4.1: (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; caesium carbonate / toluene / 26 h / 110 °C / Inert atmosphere
With
hydrogenchloride; (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; tetrabutyl ammonium fluoride; ammonia; potassium; caesium carbonate; tert-butyl alcohol;
In
tetrahydrofuran; 1,4-dioxane; water; toluene;
1.1: Birch reduction;
DOI:10.1002/anie.201103450
