5-Bromo-2-(piperidin-1-yl)pyridine

Base Information

• Chemical Name: 5-Bromo-2-(piperidin-1-yl)pyridine
• CAS No.: 24255-95-6
• Molecular Formula: C10H13BrN2
• Molecular Weight: 240.03
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70585955
• Nikkaji Number: J1.982.168D
• Wikidata: Q82477979
• Mol file: 24255-95-6.mol

Synonyms:5-Bromo-2-(piperidin-1-yl)pyridine;24255-95-6;5-bromo-2-piperidin-1-ylpyridine;5-Bromo-2-(1-piperidinyl)pyridine;SCHEMBL3573336;DTXSID70585955;AEDSMUUEBQNEAA-UHFFFAOYSA-N;AMY36609;ZAA25595;MFCD00234654;3-Bromo-6-(piperidin-1-yl)pyridine;AKOS005159228;AB05271;AS-48203;CS-0194451;F19739;J-015414;J-516851;Z808607072

Chemical Property of 5-Bromo-2-(piperidin-1-yl)pyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 333.852 °C at 760 mmHg
• Flash Point: 155.708 °C
• PSA: 16.13000
• Density: 1.409 g/cm³
• LogP: 2.89940
• Storage Temp.: 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 240.02621
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-(piperidin-1-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=NC=C(C=C2)Br

Technology Process of 5-Bromo-2-(piperidin-1-yl)pyridine

There total 5 articles about 5-Bromo-2-(piperidin-1-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

piperidine (110-89-4) + 2,5-dibromopyridine (624-28-2) → 5'-bromo-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl (24255-95-6)

Guidance literature:

With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 100 ℃; for 3h;

DOI:10.1021/ol0357696

Reference yield: 84.0%

piperidine (110-89-4) + trifluoromethanesulfonic acid 5-bromo-pyridin-2-yl ester (475106-12-8) → 5'-bromo-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl (24255-95-6)

Guidance literature:

In DMF (N,N-dimethyl-formamide); at 40 ℃; for 3h;

Reference yield: 47.0%

piperidine (110-89-4) + 5-bromo-2-chloropyridine (53939-30-3) → 5'-bromo-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl (24255-95-6)

Guidance literature:

With 1,1'-bis[bis(dimethylamino)phosphino]ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In 1,4-dioxane; at 70 ℃; for 15h; Sealed tube; Inert atmosphere;

DOI:10.1021/jacs.7b05409

upstream raw materials:

piperidine

2,5-dibromopyridine

carbon monoxide

trifluoromethanesulfonic acid 5-bromo-pyridin-2-yl ester

Downstream raw materials:

6-(piperidin-1-yl)nicotinonitrile

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