4-(4-Hydroxy-1-piperidinyl)ethyl benzoate

Base Information

• Chemical Name: 4-(4-Hydroxy-1-piperidinyl)ethyl benzoate
• CAS No.: 25437-94-9
• Molecular Formula: C14H19NO3
• Molecular Weight: 249.31
• Hs Code.: 2933399090
• Mol file: 25437-94-9.mol

Synonyms:1-(4-Ethoxycarbonylphenyl)-4-piperidinol;ethyl 4-(4-hydroxypiperidin-1-yl)benzoate;4-(4-hydroxypiperidin-1-yl)benzoic acid ethyl ester;ethyl 4-(4-hydroxy-1-piperidinyl)benzoate;4-(4-Hydroxy-1-piperidinyl)ethyl benzoate;

Chemical Property of 4-(4-Hydroxy-1-piperidinyl)ethyl benzoate

Chemical Property:

• PSA: 60.77000
• LogP: 1.32190

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-(4-hydroxypiperidin-1-yl)benzoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Hydroxy-1-piperidinyl)ethyl benzoate

There total 1 articles about 4-(4-Hydroxy-1-piperidinyl)ethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-HYDROXYPIPERIDINE (5382-16-1) + 4-fluorobenzoic acid ethyl ester (451-46-7) → ethyl 4-(4-hydroxypiperidin-1-yl)benzoate (25437-94-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 32h; Inert atmosphere;

Reference yield: 92.0%

ethyl 4-(4-hydroxypiperidin-1-yl)benzoate (25437-94-9) → 4-(4-Hydroxy-1-piperidinyl)benzoic acid monohydrochloride (553672-07-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 90 ℃; for 1.5h;

Reference yield: 66.0%

ethyl 4-(4-hydroxypiperidin-1-yl)benzoate (25437-94-9) → 4-(4-Oxo-1-piperidinyl)benzoic acid ethyl ester (25437-95-0)

Guidance literature:

With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In benzene; at 5 - 23 ℃; Cooling;

upstream raw materials:

4-HYDROXYPIPERIDINE

4-fluorobenzoic acid ethyl ester

Downstream raw materials:

4-(4-Oxo-1-piperidinyl)benzoic acid ethyl ester

ethyl 4-(4-phthalimidopiperidin-1-yl)benzoate

ethyl 4-(4-aminopiperidin-1-yl)benzoate

4-{4-(Pyrimidin-2-ylamino)piperidin-1-yl}benzoic acid

Refernces

• 1、 Chen, Zhen,Mori, Wakana,Deng, Xiaoyun,Cheng, Ran,Ogasawara, Daisuke,Zhang, Genwei,Schafroth, Michael A.,Dahl, Kenneth,Fu, Hualong,Hatori, Akiko,Shao, Tuo,Zhang, Yiding,Yamasaki, Tomoteru,Zhang, Xiaofei,Rong, Jian,Yu, Qingzhen,Hu, Kuan,Fujinaga, Masayuki,Xie, Lin,Kumata, Katsushi,Gou, Yuancheng,Chen, Jingjin,Gu, Shuyin,Bao, Liang,Wang, Lu,Collier, Thomas Lee,Vasdev, Neil,Shao, Yihan,Ma, Jun-An,Cravatt, Benjamin F.,Fowler, Christopher,Josephson, Lee,Zhang, Ming-Rong,Liang, Steven H.. "Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "tail Switching" Strategy on a Piperazinyl Azetidine Skeleton". supporting information. p. 3336 - 3353. Retrieved 2019/03/29.
• 2、 -. "TREATMENT OF DISEASES BY EPIGENETIC REGULATION". Paragraph 0445. . Retrieved 2013/11/05.