1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester

Base Information

• Chemical Name: 1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester
• CAS No.: 1375152-56-9
• Molecular Formula: C₄₆H₅₄N₄O₁₈
• Molecular Weight: 950.951
• Mol file: 1375152-56-9.mol

Synonyms:1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester

Chemical Property of 1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester

There total 1 articles about 1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-methoxy-2-nitro-benzaldehyde (20357-24-8) + 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester (73630-07-6) → 1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester (1375152-56-9)

Guidance literature:

5-methoxy-2-nitro-benzaldehyde; 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester; With 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; for 72h; Darkness; Inert atmosphere;

With tetrabutyl ammonium fluoride; In chloroform; at 20 ℃; for 0.5h; Darkness;

DOI:10.1021/ja2115184

Reference yield: 96.0%

1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester (1375152-56-9) → 1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid (1375152-58-1)

Guidance literature:

With water; sodium hydroxide; at 20 ℃;

DOI:10.1021/ja2115184

Reference yield:

1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester (1375152-56-9) → 1,2-bis{2-amino-5-[(5-methoxy-2-nitrosophenyl)carbonyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid + 1-{2-amino-5-[(5-methoxy-2-nitrosophenyl)carbonyl]phenoxy}-2-{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]phenoxy}-ethane-N,N,N',N'-tetraacetic acid

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium hydroxide / 20 °C

2: dimethyl sulfoxide / Photolysis

With water; sodium hydroxide; In dimethyl sulfoxide;

DOI:10.1021/ja2115184

upstream raw materials:

5-methoxy-2-nitro-benzaldehyde

1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid tetraethyl ester

Downstream raw materials:

1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid