1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid

Base Information

Chemical Name:1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid
CAS No.:1375152-58-1
Molecular Formula:C₃₈H₃₈N₄O₁₈
Molecular Weight:838.736
Hs Code.:

Synonyms:1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid

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Chemical Property of 1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid

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Technology Process of 1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid

There total 3 articles about 1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1375152-56-9
1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid tetraethyl ester

: 1375152-58-1
1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid

Guidance literature:: With water; sodium hydroxide; at 20 ℃;
DOI:10.1021/ja2115184

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 1375152-58-1
1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 72 h / Darkness; Inert atmosphere

2.2: 0.5 h / 20 °C / Darkness

3.1: water; sodium hydroxide / 20 °C

With 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate; water; potassium carbonate; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja2115184

Reference yield:

: 20357-24-8
5-methoxy-2-nitro-benzaldehyde

: 1375152-58-1
1,2-bis{2-amino-5-[(5-methoxy-2-nitrophenyl)hydroxymethyl]-phenoxy}ethane-N,N,N',N'-tetraacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 72 h / Darkness; Inert atmosphere

1.2: 0.5 h / 20 °C / Darkness

2.1: water; sodium hydroxide / 20 °C

With 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate; water; sodium hydroxide; In dichloromethane;
DOI:10.1021/ja2115184