(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

Base Information

Chemical Name:(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
CAS No.:840528-23-6
Molecular Formula:C₃₉H₄₉FN₂O₄Si
Molecular Weight:656.913
Hs Code.:

(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

Synonyms:(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

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Chemical Property of (2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

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Technology Process of (2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

There total 1 articles about (2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 842162-99-6
(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

: 840528-23-6
(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -80 ℃;

Reference yield: 83.0%

: 840528-23-6
(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

: 842163-03-5
1-[2-((2R,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide

Guidance literature:: (2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide; With water; acetic acid; In tetrahydrofuran; at 20 ℃; for 96h;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; pH=7 - 8; Product distribution / selectivity;