4-tert-ButyldiMethylsilyl Atorvastatin Lactone

Base Information

• Chemical Name: 4-tert-ButyldiMethylsilyl Atorvastatin Lactone
• CAS No.: 842162-99-6
• Molecular Formula: C39H47FN2O4Si
• Molecular Weight: 654.897
• Mol file: 842162-99-6.mol

Synonyms:4-tert-Butyldimethylsilyl Atorvastatin Lactone;

Chemical Property of 4-tert-ButyldiMethylsilyl Atorvastatin Lactone

Chemical Property:

• PSA: 69.56000
• LogP: 9.89600
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

4-tert-Butyldimethylsilyl Atorvastatin Lactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-tert-Butyldimethylsilyl Atorvastatin Lactone is a derivative of Atorvastatin Lactone (A791780), used in the preparation of N-substituted pyrrole derivatives as intermediates in the synthesis of atorvastatin.

Technology Process of 4-tert-ButyldiMethylsilyl Atorvastatin Lactone

There total 1 articles about 4-tert-ButyldiMethylsilyl Atorvastatin Lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

atorvastatin lactone (125995-03-1) + tert-butyldimethylsilyl chloride (18162-48-6) → (2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide (842162-99-6)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide;

Reference yield: 99.0%

(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide (842162-99-6) → (2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide (840528-23-6)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -80 ℃;

upstream raw materials:

atorvastatin lactone

tert-butyldimethylsilyl chloride

Downstream raw materials:

(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-hydroxytetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

Refernces