6-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylphenyl)-3-morpholinoquinolin-2-amine

Base Information

Chemical Name:6-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylphenyl)-3-morpholinoquinolin-2-amine
CAS No.:1319194-56-3
Molecular Formula:C₂₄H₂₄ClN₅O
Molecular Weight:433.94
Hs Code.:

Synonyms:6-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylphenyl)-3-morpholinoquinolin-2-amine

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Chemical Property of 6-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylphenyl)-3-morpholinoquinolin-2-amine

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Technology Process of 6-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylphenyl)-3-morpholinoquinolin-2-amine

There total 6 articles about 6-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylphenyl)-3-morpholinoquinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1319197-06-2
4-chloro-1-(2-iodo-3-methylphenyl)-3-methyl-1H-pyrazole

: 1319196-52-5
3-morpholino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-2-amine

: 1319194-56-3
6-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylphenyl)-3-morpholinoquinolin-2-amine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 140 ℃; for 0.25h; microwave irradiation; Inert atmosphere; Sealed vessel;

Reference yield:

: 29124-57-0
2-amino-5-bromobenzaldehyde

: 1319194-56-3
6-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylphenyl)-3-morpholinoquinolin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / dimethyl sulfoxide / 4 h / 80 °C

1.2: 20 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 85 °C / Inert atmosphere

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 140 °C / microwave irradiation; Inert atmosphere; Sealed vessel

With water; potassium acetate; sodium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield:

: 53848-17-2
2-bromo-6-methylaniline

: 1319194-56-3
6-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylphenyl)-3-morpholinoquinolin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 18 h / 110 °C / Inert atmosphere

2.1: hydrogenchloride; sodium nitrite; sulfuric acid / water / 0.67 h / 0 °C

2.2: 0 - 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 140 °C / microwave irradiation; Inert atmosphere; Sealed vessel

With hydrogenchloride; sulfuric acid; sodium carbonate; potassium carbonate; sodium nitrite; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N`-dimethylethylenediamine; In 1,4-dioxane; water; toluene;